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M94A2831.TXT
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1994-10-25
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Document 2831
DOCN M94A2831
TI AHCC immunotherapy in AIDS patients.
DT 9412
AU Ghoneum M; Priestly J; Drew Univ. of Med. & Sci., Dept. of
Otolaryngology, L.A., CA; 90059.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):215 (abstract no. PB0291). Unique
Identifier : AIDSLINE ICA10/94369744
AB OBJECTIVE: We evaluated the immunologic effects of Active Hemicellulose
Compound (AHCC) therapy for 12 months in 20 HIV positive homosexual men.
AHCC is a mycelic extract of Basidiomycota which was originated from
hybridization of several types of mushrooms. METHODS: Patients were
given AHCC 3 g/d daily. The following parameters were examined; NK cell
activity, absolute counts and percentages of CD4+ and CD8+ cells and the
ratio of CD4/CD8. RESULTS: Treatment with AHCC resulted in: 1)
Significant induction of NK cytotoxicity occurred at one month (220%)
and maximized at 3 mon (440%) and was maintained at this high level. 2)
Marked increase in the absolute CD4+ cell counts in 14/20 patients
(120%) at one month and continued at the same level. 3) No change in
percentage of CD4+ cells. 4) Significant increase in absolute CD8 cell
counts in 12/20 patients (137%). 5) No change in CD4/CD8 ratio.
DISCUSSION AND CONCLUSIONS: We concluded that AHCC is a potent
immunomodulator, with potential therapeutic role in the stimulation of
host immune response against HIV. Its importance requires further
studies for clinical trials.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*THERAPY Adjuvants,
Immunologic/PHARMACOLOGY/*THERAPEUTIC USE Cytotoxicity,
Immunologic/DRUG EFFECTS CD4-CD8 Ratio/DRUG EFFECTS Drug Evaluation
Human Killer Cells, Natural/DRUG EFFECTS Leukocyte Count/DRUG EFFECTS
Male Polysaccharides/PHARMACOLOGY/*THERAPEUTIC USE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).